Site Manager

Sheffield, UK

Competitive

We’re supporting a leading pharmaceutical manufacturing organisation with a network of UK sites delivering critical diagnostic products. With continued growth, operational complexity, and regulatory expectations, we are seeking an experienced Site Manager to take full operational ownership of a key facility.

Reporting to the Head of Operations, with a functional relationship to Quality leadership, this is a highly visible role responsible for ensuring the safe, compliant, and efficient manufacture and distribution of pharmaceutical products.

This role combines hands-on operational leadership with strategic oversight, and would suit an experienced manufacturing or pharmaceutical professional with strong GMP knowledge and a track record of managing matrix teams in a regulated environment.

Key Responsibilities

Lead all site operations, including production, quality control, engineering, and maintenance.
Ensure compliance with current Good Manufacturing Practice (cGMP), GLP, and all regulatory requirements (MHRA, HSE, Environment Agency).
Manage and develop a multidisciplinary team, including Production, QC, and Engineering Managers, ensuring effective staffing, training, and performance.
Collaborate closely with Quality leadership, Qualified Persons (QPs), and QA teams to maintain robust Quality Management Systems (QMS).
Oversee production planning and execution.
Ensure site readiness and operational uptime, including plant, utilities, and critical infrastructure (e.g., air handling, power, gases).
Lead maintenance and engineering activities, including fault resolution, contractor management, and spare parts control.
Support new product introduction and validation activities, working cross-functionally with QA and technical teams.
Act as deputy for the Head of Operations when required and represent the site in internal and external engagements.

Requirements

Essential

Proven experience in pharmaceutical manufacturing environments.
Strong working knowledge of GMP and regulatory compliance (MHRA or equivalent).
Demonstrated experience managing matrix teams.
Experience overseeing site operations, production processes, and maintenance systems.
Strong leadership and organisational skills with the ability to drive performance and operational excellence.
Experience with quality systems, SOPs, deviations, and compliance frameworks.

Desirable

Experience in radiopharmaceuticals, aseptic or sterile manufacturing.
Familiarity with cyclotron operations or PET/SPECT production environments.
Experience supporting validation and new product introduction (NPI).
Prior involvement in regulatory inspections or audits.

Apply Now

Discipline

Job Ref

PR/030210 a

Published

1 day ago

Expiry

8 Jun 2026 23:59

Ayesha Kippie

Associate Manager

Ayesha.Kippie@rbwconsulting.com

+44 (0)1293 584 300

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