Associate/Director of Computational Chemistry
Location | California |
Job ref: | SD-AD-CC |
Published: | 6 months ago |
Expiry date: | 30 Apr 2024 23:59 |
As the
ASSOCIATE/DIRECTOR, COMPUTATIONAL CHEMISTRY, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Structural biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects.
You will contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics.
You will implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts.
Responsibilities:
Responsible for visibility and representation of Computational Chemistry Accomplishments to the executive team.
Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
Provide important technical knowledge and input to project teams to drive decision making in drug discovery projects.
Manage and mentor a Strong team of Computational Chemists to high productivity levels
Requirements:
PhD degree in a Computational Chemistry with 10+ years experience in Pharma/Biotech
10+ years of Industry experience including 2+ years in leadership roles and mentoring direct reports is required
Strong expertise in a variety of computational tools and methodologies including Docking, Virtual screening, Molecular dynamics, Free energy perturbation, Homology modeling, Quantum mechanics, Pharmacophore elucidation, Data mining, Cheminformatics, Clustering, Similarity & Diversity analysis.
Strong Impact on progressing Discovery Projects from Hits to Clinical Leads
Strong knowledge & experience in using a variety of tools for Hit ID
Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.
Contribute to the design, development and deployment of AI platforms to impact drug discovery.
Identify and implement novel computational chemistry algorithms, technologies, and workflows.
Strong Proficiency with state of the art Computational chemistry software.
Proficiency in scientific scripting and programming languages
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